If your wrists are hurting you may have some repetitive stress related injuries. Most likely your keyboard is too high or low. You can reduce the stress by raising/lowering your keyboard and/or chair. There are plenty of guides on how to optimize your seating and keyboard positioning.
A wrist rest/pad/support may also help. You can buy these made from foam or gel, whichever you find is most comfortable. You can also try rolling up a small towel or cloth.
Those split "ergonomic" keyboards take some getting used to but many people swear by them. Switching back and forth between both types of keyboards can be difficult (i.e. between home and work).
You can also get glow-in-the-dark labels and stick them on the sides of the keys you need to find. There are also programmable keypads or macros that you can set for one key press for multiples or combination keystrokes.