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Thread: Kinda interesting article about possible use

  1. #1
    Somewhat Unstable superimposedhope's Avatar
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    Mycologist Paul Stamets tests over 100 mushroom extracts with NIH and USAMRIID.
    Several show selective potent anti-viral properties.


    Kamilche Point, Washington 24 March 2005 – Recent in vitro tests demonstrate that a
    specially prepared extract from Fomitopsis officinalis is highly selective against viruses. F.
    officinalis is a wood conk mushroom, known for thousands of years as Agarikon. It is
    extinct or nearly so in Europe and Asia, and is still found in the old-growth forests of the
    American Pacific Northwest. It may provide novel anti-viral drugs useful for protecting against
    pox and other viruses.


    That is the forecast of Paul Stamets, owner and director of the research laboratories of
    Fungi Perfecti of Kamilche Point, Washington. He is a mycologist—a fungus expert. For the
    past two years, Stamets has prepared more than a hundred strains of medicinal mushroom
    extracts for testing by the National Institute of Allergy and Infectious Diseases (NIAID), part of
    the National Institutes of Health and the US Army Medical Research Institute of Infectious
    Diseases (USAMRIID), in their joint biodefense antiviral screening program. The results to
    date promise breakthroughs on this biomedical frontier.


    Dr. John A. Secrist III, vice president of Southern Research Institute’s Drug Discovery
    Division, who oversees an NIAID contract to evaluate potential antiviral drugs, notes that
    “Several of Stamets’ medicinal mushroom extracts have shown very interesting activity
    against pox viruses in cell culture assays performed through NIAID, and we are hopeful that
    they will also prove effective in the animal model systems. The number of different classes of
    compounds that show promising activity is small, so finding something new would be of great
    benefit to the scientific community.” In fact, of more than 200,000 samples submitted over
    several years, only a handful are slated for animal testing each year. In the past year,
    approximately ten samples showed activity warranting approval for animal testing; of these,
    two are from strains of Agarikon discovered by Stamets. Moreover, Mr. Stamets’ samples are
    the only natural products extracts tested through this program that have demonstrated very
    active anti-pox activity.



    The NIH/USAMRIID screening program tests the mushroom extracts against viruses that
    could be weaponized, including the viruses causing yellow fever, dengue, SARS, respiratory
    viruses, and pox viruses. Of the Agarikon samples submitted to date, several showed potent
    activity for reducing infection from vaccinia and cowpox, which are in the same family as the
    smallpox virus. These extracts show activity against vaccinia and cowpox by two different viral
    evaluations, demonstrating the reproducibility of the results. Stamets has filed several patents,
    both US and international, on the anti-viral properties of mushrooms in the Fomitopsis
    family. However, only compounds derived using Mr. Stamets’ proprietary, patent-pending
    methodology for cell cultures show activity; simple extracts from the woody conks (such as tea
    or infusions) are not active. Harvesting these rare conks from the forests will not provide
    therapeutic benefits and could impair the reproduction of the fungus.



    While several strains of extract generated strong anti-pox activity, other strains were less
    potent. This underscores the importance of conserving mycodiversity. More potent strains may
    yet be discovered. As for F. officinalis, this mushroom was first described 2000 years ago as
    an anti-inflammatory medicine by Dioscorides, the Greek physician in his text Materia Medica.


    “The ecological niche for these unique mushrooms is increasingly jeopardized as humans
    destroy old-growth habitats,” comments Stamets. “As this happens, the pool of available
    strains will be further reduced. Acquiring as many strains as possible should be an
    international priority so that preventive or curative medicines against pox and related viruses
    can be developed. Personally, I believe we should be saving our old growth forests as a
    matter of national defense.” Besides having a direct anti-viral or anti-bacterial effect,
    mushroom derivatives can also activate the natural immune system. Evaluations in an animal
    model are planned for the near future. “Until then,” Stamets cautions, “we cannot draw
    conclusions about the ultimate effectiveness of these mycologically based antivirals.” Testing
    against other viruses continues. Stamets has already been granted a patent on fungus-derived
    products; several more are in the offing. His research has been self-funded from his other
    businesses.


    yet2.com is Stamets’ partner for licensing and commercializing his intellectual property.



    About Fungi Perfecti



    Paul Stamets has written six books, several used as textbooks around the world by the
    gourmet and medicinal mushroom industry. Fungi Perfecti, LLC ( www.fungi.com) was founded
    in 1980; it has four laboratories, 10,000 sq. ft. of clean rooms, and is equipped with 17
    laminar flow benches for doing in vitro propagation work. The culture collection of Fungi
    Perfecti consists of hundreds of cultures of medicinal mushrooms, many isolated from the old-
    growth forests of the Pacific Northwest. Stamets has received several environmental awards,
    including the 1998 "Bioneers Award" from The Collective Heritage Institute, and the 1999
    "Founder of a New Northwest Award" from the Pacific Rim Association of Resource
    Conservation and Development Councils. He is an advisor to the Program of Integrative
    Medicine at the University of Arizona, Tucson; serves on the Editorial Board of The
    International Journal of Medicinal Mushrooms, and was appointed to the G.A.P. (Good
    Agricultural Practices)/G.M.P. (Good Manufacturing Practices) advisory board of the U.S.
    Pharmacopoeia. Dr. Andrew Weil and David Eisenberg of Harvard Medical School are
    recommending Stamets’ products for immune support. Stamets is the sole-source supplier
    and co-investigator of the first NIH-funded clinical study using medicinal mushrooms in the
    United States. He is involved in several other research trials ongoing and pending. His
    company is the sponsor of the Third International Medicinal Mushroom Conference to be held
    in Port Townsend, Washington Oct. 12-17, 2005 where researchers from around the world
    will convene to discuss the latest developments in the use of medicinal mushrooms as sources
    for new antiviral and anticancer drugs.


    About USAMRIID



    The US Army Medical Research Institute of Infectious Diseases, located at Fort Detrick,
    Maryland, is the lead medical research laboratory for the U.S. Biological Defense Research
    Program, and plays a key role in national defense and in infectious disease research. The
    Institute’s mission is to conduct basic and applied research on biological threats resulting in
    medical solutions (such as vaccines, drugs and diagnostics) to protect the warfighter.
    USAMRIID is a subordinate laboratory of the U.S. Army Medical Research and Materiel
    Command.



    About yet2.com Inc.



    yet2.com provides intellectual property consulting and licensing services to clients around
    the globe. yet2.com Inc and its online marketplace was founded in 1999 to promote
    technology licensing and transfer, with joint investment from Siemens, Bayer, Honeywell,
    DuPont, Procter & Gamble, Caterpillar, and NTT Leasing. The privately-held company has
    offices in the United States, Europe, and Japan. Its clientele consists of a quarter of the
    Fortune 1000. yet2.com draws upon its global network of technology leaders in thousands of
    companies across all industries, to establish productive dialogs quickly
    \"There is nothing here of interest to any nation, as a matter of fact there is nothing here but humans!\"

  2. #2
    Somewhat Unstable superimposedhope's Avatar
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    One of his funding businesses is where I get my Mycorrhiza from - good stuff.

    Joe
    \"There is nothing here of interest to any nation, as a matter of fact there is nothing here but humans!\"

  3. #3
    Stay chooned in for more! Clint's Avatar
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    lol, when i saw this i wasn't thinking what you were thinking.

    first word i thought of was "locked" lol

  4. #4
    Somewhat Unstable superimposedhope's Avatar
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    [img]http://www.**********.com/iB_html/non-cgi/emoticons/new/smile_k_ani_32.gif[/img] [img]http://www.**********.com/iB_html/non-cgi/emoticons/new/smile_m_32.gif[/img]

    Not that kind of mushroom, silly boy!
    \"There is nothing here of interest to any nation, as a matter of fact there is nothing here but humans!\"

  5. #5

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    I REALLY want to buy some of the mushroom kits but dang I'm so cheap!
    anyway... this isn't just about mycodiversity, but biodiversity. conservation people!
    Talk sense to a fool and he calls you foolish-Euripides
    wikipedia rocks! (except for species info)(CPers-add your vast knowledge of CPs to wikipedia&#33
    A person is smart. People are dumb, panicky, dangerous animals and you know it
    Get all the fools on your side and you can be elected to anything

  6. #6
    Stay chooned in for more! Clint's Avatar
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    lol, you remind me of Carson when you say that. he says "Fashion, people!"

  7. #7

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    [img]http://www.**********.com/iB_html/non-cgi/emoticons/new/confused.gif[/img] ...o..k... lol
    I have no clue who that is :P
    Talk sense to a fool and he calls you foolish-Euripides
    wikipedia rocks! (except for species info)(CPers-add your vast knowledge of CPs to wikipedia&#33
    A person is smart. People are dumb, panicky, dangerous animals and you know it
    Get all the fools on your side and you can be elected to anything

  8. #8
    Somewhat Unstable superimposedhope's Avatar
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    Who is Carson?
    \"There is nothing here of interest to any nation, as a matter of fact there is nothing here but humans!\"

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