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Thread: Wolverine the superhero= owned by mice

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    It's a miracle: mice regrow hearts

    August 29, 2005
    SCIENTISTS have created "miracle mice" that can regenerate amputated limbs or damaged vital organs, making them able to recover from injuries that would kill or permanently disable normal animals.

    The experimental animals are unique among mammals in their ability to regrow their heart, toes, joints and tail.

    And when cells from the test mouse are injected into ordinary mice, they too acquire the ability to regenerate, the US-based researchers say.

    Their discoveries raise the prospect that humans could one day be given the ability to regenerate lost or damaged organs, opening up a new era in medicine.

    Details of the research will be presented next week at a scientific conference on ageing titled Strategies for Engineered Negligible Senescence, at Cambridge University in Britain.









    The research leader, Ellen Heber-Katz, professor of immunology at the Wistar Institute, a US biomedical research centre, said the ability of the mice at her laboratory to regenerate organs appeared to be controlled by about a dozen genes.

    Professor Heber-Katz says she is still researching the genes' exact functions, but it seems almost certain humans have comparable genes.

    "We have experimented with amputating or damaging several different organs, such as the heart, toes, tail and ears, and just watched them regrow," she said.

    "It is quite remarkable. The only organ that did not grow back was the brain.

    "When we injected fetal liver cells taken from those animals into ordinary mice, they too gained the power of regeneration. We found this persisted even six months after the injection."

    Professor Heber-Katz made her discovery when she noticed the identification holes that scientists punch in the ears of experimental mice healed without any signs of scarring in the animals at her laboratory.

    The self-healing mice, from a strain known as MRL, were then subjected to a series of surgical procedures. In one case the mice had their toes amputated -- but the digits grew back, complete with joints.

    In another test some of the tail was cut off, and this also regenerated. Then the researchers used a cryoprobe to freeze parts of the animals' hearts, and watched them grow back again. A similar phenomenon was observed when the optic nerve was severed and the liver partially destroyed.

    The researchers believe the same genes could confer greater longevity and are measuring their animals' survival rate. However, the mice are only 18 months old, and the normal lifespan is two years so it is too early to reach firm conclusions.

    Scientists have long known that less complex creatures have an impressive ability to regenerate. Many fish and amphibians can regrow internal organs or even whole limbs.

    The Sunday Times

    http://www.theaustralian.news.com.au/common....00.html

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    Should this eventually be applied to humans then the whole stem cell research argument might be moot, and my dad could potentially walk again, and I could grown my pinkie back.

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    Quote Originally Posted by [b
    Quote[/b] (ALLOSAURZ @ Sep. 02 2005,6:34)]Should this eventually be applied to humans then the whole stem cell research argument might be moot, and my dad could potentially walk again, and I could grown my pinkie back.
    whats a pinkie?
    Carnivorous plants growlist:http://www.**********.com/cgi-bin....t=17597
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    I've got a magic window! elgecko's Avatar
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    My guess would be the little finger.


    My Grow List Updated 8/24/17

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    endparenthesis's Avatar
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    I saw mention of fetal liver cells in there, so we may be just as screwed as we are with stem cells.

    But they also said that they'd identified the genes involved... so some sort of gene therapy might be all that's needed eventually.

    I'm still wondering who's going to come up with a way to grow us new sets of teeth. The body knows how to do it... the process just needs to get triggered. And it's so obvious that living 100 years with teeth meant to last 30 is not going to work, that I can't believe I haven't heard of anyone working on this.

    Maybe some kind of secret society of dentists is threatening anyone who tries. [img]http://www.**********.com/iB_html/non-cgi/emoticons/new/smile.gif[/img]

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    Quote Originally Posted by [b
    Quote[/b] (endparenthesis @ Sep. 02 2005,7:59)]I saw mention of fetal liver cells in there, so we may be just as screwed as we are with stem cells.

    But they also said that they'd identified the genes involved... so some sort of gene therapy might be all that's needed eventually.

    I'm still wondering who's going to come up with a way to grow us new sets of teeth. The body knows how to do it... the process just needs to get triggered. And it's so obvious that living 100 years with teeth meant to last 30 is not going to work, that I can't believe I haven't heard of anyone working on this.

    Maybe some kind of secret society of dentists is threatening anyone who tries. [img]http://www.**********.com/iB_html/non-cgi/emoticons/new/smile.gif[/img]
    Hmmm what will probably happen with teeth if they can't be worked on through gene therapy is scientists will probably develop synthetic implants. Imagine teeth that don't stain or get cavities no matter how much soda or sweets you eat. Teeth that aren't sensitive to cold or heat. That's what I am looking forward to.

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    Sooo... if this works, then if you get cancer, they can just cut out whatever is ailing you, and let it regrow instead of using chemotherapy? Hot darn, this stuff is great.

    Now vampires aren't the only ones who can regenerate. I don't feel special anymore. [img]http://www.**********.com/iB_html/non-cgi/emoticons/new/smile_h_32.gif[/img]
    Update: Parents convinced to allow me to keep greenhouse heated over winter. Most species will not be lost. Too lazy to update growlist.

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    endparenthesis's Avatar
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    Quote Originally Posted by [b
    Quote[/b] (ALLOSAURZ @ Sep. 02 2005,8:09)]Hmmm what will probably happen with teeth if they can't be worked on through gene therapy is scientists will probably develop synthetic implants. Imagine teeth that don't stain or get cavities no matter how much soda or sweets you eat. Teeth that aren't sensitive to cold or heat. That's what I am looking forward to.
    I like it. That solves the problem of needing braces every time you regrow a set too. [img]http://www.**********.com/iB_html/non-cgi/emoticons/new/smile.gif[/img]

    I wonder what these limbs look like as they're coming in. It's probably something you want to keep covered up for a while...

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