CCrider - what kind of mushroom are you talking about, and where did you hear this? Around here (New York) the ones that release clouds of spores (puffballs) are commonly eaten, at least while they are young, before the spores are ripe. As a kid, I always poked them and watched the spores fly out. I don't know of puffballs that are poisonous when eaten, let alone when poked (though I could be wrong).
I also wouldn't recommend eating mushrooms - especially wild Amanita ssp., they're are too many similar and poisonous species. Many species are VERY hard to distinguish, even for specialists. Also, some people (none here, I hope) occasionally state that if animals or slugs are eating mushrooms, they're edible. Slugs, and even some mammals, can eat mushrooms that would poison humans.