http://www.medscape.com/viewarticle/534959
Lymphocutaneous Sporotrichosis
Days to weeks after cutaneous inoculation of the fungus, a papule develops at the site of inoculation. The primary lesion can become nodular, but most often, it ulcerates. The drainage is not grossly purulent and has no odor, and the lesion is not terribly painful. Similar lesions subsequently occur along the lymphatic channels proximal to the original lesion. A fixed cutaneous lesion that is verrucous or ulcerative and that is not associated with lymphatic extension can also occur.62
Visceral Sporotrichosis
Pulmonary sporotrichosis occurs most often in middle-aged men who have COPD and abuse alcohol.63 In contrast to most forms of sporotrichosis, systemic symptoms, including fever, night sweats, weight loss, and fatigue, are common. Dyspnea, cough, purulent sputum, and hemoptysis are common respiratory symptoms. A chest radiograph shows unilateral or bilateral upper-lobe cavities with variable amounts of fibrosis and nodular lesions.
Osteoarticular sporotrichosis is found most often in middle-aged men and occurs more frequently in patients with alcoholism.64 Although some patients experience osteoarticular involvement after local inoculation, this form of infection most often develops through hematogenous spread. Infection may involve one joint or multiple joints. The joints most commonly affected are the knee, elbow, wrist, and ankle. Isolated cases of bursitis and tenosynovitis, sometimes presenting as nerve entrapment syndromes, have been reported.
S. schenckii has rarely been reported to cause localized infection of the meninges, pericardium, eye, perirectal tissues, larynx, breast, epididymis, spleen, liver, bone marrow, or lymph nodes.60 Disseminated sporotrichosis is very uncommon, with cases occurring primarily in patients with advanced HIV infection. Most patients have widespread ulcerative cutaneous lesions and may or may not have visceral dissemination.
Infectious Disease
Mycotic Infections: Sporotrichosis
From ACP Medicine Online
Carol A. Kauffman, MD, FACP