If you care for it well, it shouldn't matter much. I had a rokko x fallax that started getting brown spots on all of its leaves. I posted about it in 2 diff forums, and i was told possible overwater, or too much light, and i can assure you, neither of those were the case. Either way, I air-layered the thing, and the plant with the brown spots on the leaves (the "old" part of the plant) sent out 2 normal and vigorous new growing points out of the nodes. Usually my plan of action for nep ailments (with the exception of fungus/bugs) is to do absolutely nothing, unless the problem appears to worsen over about a month. Things usually sort themselves out